GWAS-related eQTLs across different cancer types
We identified 337,131 eQTLs that overlap with GWAS linkage disequilibrium (LD) regions (r² ≥ 0.5).
|
Cancer type
|
eQTL type
|
tagSNP
|
Gene position (hg19)
|
p-value
|
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| BLCA | cis | rs2275426 | 1 | rs809775 | chr1:46538040 | CCDC163P | chr1:45960581-45965646:- | -0.33 | -6.22 | 1.28E-9 | Body mass index |
| BLCA | cis | rs2275426 | 1 | rs809775 | chr1:46538040 | MUTYH | chr1:45794915-45806142:- | 0.2 | 3.9 | 0.000115 | Body mass index |
| BLCA | cis | rs8102137 | 1 | rs8102137 | chr19:30296853 | CCNE1 | chr19:30302901-30315218:+ | 0.21 | 3.9 | 0.000112 | Bladder cancer |
| BLCA | cis | rs7246967 | 1 | rs8113312 | chr19:23061182 | ZNF492 | chr19:22817126-22850472:+ | -0.3 | -4.1 | 5.0E-5 | Bronchopulmonary dysplasia |
| BLCA | cis | rs8133949 | 1 | rs8133949 | chr21:43421114 | C21orf121 | chr21:43442113-43445060:+ | 0.32 | 4.57 | 6.52E-6 | Hand grip strength |
| BLCA | cis | rs8141797 | 1 | rs8138799 | chr22:24556902 | SUSD2 | chr22:24577444-24585074:+ | 0.53 | 5.37 | 1.35E-7 | Amyotrophic lateral sclerosis |
| BLCA | cis | rs2076028 | 1 | rs8140617 | chr22:38970439 | JOSD1 | chr22:39081549-39096459:- | 0.23 | 3.89 | 0.000116 | Resting heart rate |
| BLCA | cis | rs8141797 | 1 | rs8141797 | chr22:24582041 | SUSD2 | chr22:24577444-24585074:+ | -0.52 | -5.69 | 2.53E-8 | Amyotrophic lateral sclerosis |
| BLCA | cis | rs703842 | 1 | rs8181644 | chr12:58173466 | FAM119B | chr12:58166383-58176323:+ | 0.27 | 4.21 | 3.22E-5 | Multiple sclerosis |
| BLCA | cis | rs703842 | 1 | rs8181644 | chr12:58173466 | TSFM | chr12:58176536-58191367:+ | -0.41 | -7.17 | 3.82E-12 | Multiple sclerosis |
| BLCA | cis | rs703842 | 1 | rs8181644 | chr12:58173466 | XRCC6BP1 | chr12:58335445-58351051:+ | -0.25 | -4.26 | 2.62E-5 | Multiple sclerosis |
| BLCA | cis | rs7611238 | 1 | rs823301 | chr3:195123495 | C3orf21 | chr3:194789015-194991895:- | -0.28 | -5.38 | 1.28E-7 | Body mass index |
| BLCA | cis | rs7611238 | 1 | rs823302 | chr3:195104741 | C3orf21 | chr3:194789015-194991895:- | -0.29 | -5.66 | 2.93E-8 | Body mass index |
| BLCA | cis | rs7611238 | 1 | rs823306 | chr3:195108320 | C3orf21 | chr3:194789015-194991895:- | -0.29 | -5.54 | 5.62E-8 | Body mass index |
| BLCA | cis | rs7611238 | 1 | rs823310 | chr3:195127093 | C3orf21 | chr3:194789015-194991895:- | -0.29 | -5.54 | 5.62E-8 | Body mass index |